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human skin fibroblast bj 1 cell lines  (ATCC)


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    ATCC human skin fibroblast bj 1 cell lines
    Human Skin Fibroblast Bj 1 Cell Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 476 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+skin+fibroblast+bj+1+cell+lines/Human+skin+fibroblast/pmc12423761-235-11-21
    Average 95 stars, based on 476 article reviews
    human skin fibroblast bj 1 cell lines - by Bioz Stars, 2026-09
    95/100 stars

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    Article Title: Click chemistry-based synthesis of new 1,2,3-triazolo-benzoquinoline-3-carbonitriles: anticancer screening and DFT studies
    Article Snippet: This study emphasizes the synthesis of a novel series of 1,2,3-triazolo-benzoquinoline-3-carbonitriles by using Cu(I)-catalyzed azide–alkyne cycloaddition known as the click reaction.. The reaction of novel acetylenic aryl-benzoquinoline-3-carbonitriles 7–12 with 1-azido-2,5-dimethoxy-4-nitrobenzene 13 afforded the corresponding 1,2,3-triazolo-benzoquinoline-3-carbonitriles 14–19 in good yields.. The desired products were examined against different tumor cells such as the human colon (HCT-116), hepatocellular carcinoma (HepG2), human breast adenocarcinoma (MCF-7) and one human healthy cell line (BJ-1) using the LDH assay.

    Article Title: Anticancer activity of new triazolopyrimidine linked coumarin and quinolone hybrids: Synthesis, molecular modeling, TrkA, PI3K/AKT and EGFR inhibition
    Article Snippet: A series of coumarin and quinolone based triazolopyrimidines was designed and synthesized utilizing molecular hybridization approach, the derivatives were examined for their antiproliferative activity against HCT-116, HepG2, MCF-7 and normal cells using the LDH assay.. The results revealed that most of the synthesized compounds exhibited notable activity towards cancer cells with no cytotoxicity on normal cells.. Compounds 4a and 4e were investigated for their Trk, PI3K/AKT and EGFR inhibitory activities.

    Article Title: Design, synthesis and molecular modeling of new coumarin–thiazole derivatives as dual EGFR/HDAC1 inhibitors: in vitro and in vivo anticancer assays
    Article Snippet: MCF-7 (human breast adenocarcinoma), HCT116 (human colorectal carcinoma) and the normal human skin fibroblast (BJ-1) cell lines were purchased from the American Type Culture Collection (Rockville, MD, USA) and maintained in the RPMI-1640 medium, which was supplemented with 10% heat-inactivated FBS, 100 U per mL penicillin, and 100 U per mL streptomycin.

    Article Title: Synthesis and Anticancer Activity Evaluation of New 1,2,4-Triazolyl-Quinazoline Hybrid Compounds and Their Pyrazolopyridine Analogs
    Article Snippet: 1,2,4-Triazolopyrimidinen and their isostericanalogs such as triazolopyridine have possessed their interest in, the literature, due to the reported broad spectrum of bioactivities, one of which is the anticancer activity.. In the current study, new functionalized 1,2,4-triazoles-based substituted quinazolinesystems were prepared via multistep reactions starting from simple starting compounds.. The reactions lead to the formation of the biand tricyclic 1,2,4-triazolopyridine and 1,2,4triazolopyrimidine compounds from the S-alkyl hydrazide, the ester and the hydrazine derivatives of the quinazoline system, respectively.

    Article Title: Synthesis, Characterization and Antitumor Activity of Benzimidazole Phosphonate Derivatives
    Article Snippet: A series of Benzimidazole derivatives were obtained via reaction of 2-chloro-1H-benzo[d]imidazole (1) with morpholine, which produce benzo[d]imidazol-yl-morpholine 2 that react with chloroacetonitrile to give (benzo[d]imidazol-yl)acetonitrile 3, by its next reaction with hydrazine hydrate afforded the key intermediate 4, that afford thiadiazole derivatives 5 by its reaction with carbon disulfide via cyclization reaction.. Alkylation of compound 5 with ethyl bromoacetate, afforded benzo[d]imidazolo derivative 6, that react with thioglycolic acid to give thiazolidine compound in suitable conditions.. Also Benzimidazole 1 reacted with various Wittig Horner reagents in DMF to afford phosphoryl and phosphonates derivatives 12a-e in moderate yields.

    Article Title: Naturally based pyrazoline derivatives as aminopeptidase N, VEGFR2 and MMP9 inhibitors: design, synthesis and molecular modeling
    Article Snippet: MCF-7 (human breast adenocarcinoma), and the normal human skin fibroblast (BJ-1) cell lines were purchased from the American Type Culture Collection (Rockville, MD, USA) and maintained in RPMI-1640 medium which was supplemented with 10% heat-inactivated FBS, 100 U ml −1 penicillin and 100 U ml −1 streptomycin.

    Cell Culture:

    Article Title: Synthesis of Some 1,2,3-triazole-bridged glycosides with benzoquniline-3-carbonitriles via click chemistry for anticancer, and docking evaluation
    Article Snippet: Novel benzoquniline-3-carbonitriles substituted 1,2,3-triazole glycosides were synthesized by using Cu(I)Catalyzed Azide-Alkyne Cycloaddition (CuAAC) known as Click reaction.. The reaction of 2,3,4,6-tetra-Oacetyl-β-D-galactopyranosyl and/or 2,3,4-tri-O-acetyl-β-D-xylopyranosyl azides 1,2 with the acetylenic arylbenzoqunioline-3-carbonitriles 3–6 afforded the corresponding 1,2,3-triazole acetylated N-glycoside products 7–11, which deacetylated using a saturated ammonia/methanol solution to produce the derived 1,2,3-triazole-N-glycosides 12–16, respectively.. All the synthesized compounds have been characterized by IR, NMR (1H and 13C) spectroscopic techniques, mass spectra and elemental analyses.

    Modification:

    Article Title: Characterization of C-phycocyanin antioxidant, anti-inflammatory, anti-tumour, and anti-HCoV-229E activities and encapsulation for implementation in an innovative functional yogurt
    Article Snippet: .. Human colorectal carcinoma (HCT-116), human liver carcinoma (HepG-2), MCF-7 (human breast adenocarcinoma), and the normal human skin fibroblast (BJ-1) cell lines were purchased from the American Type Culture Collection (Rockville, MD, USA) and maintained in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10 % heat-inactivated fetal bovine serum (FBS), 100 U ml −1 penicillin, and 100 U ml −1 streptomycin. ..



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